Neural stem progenitor cells (NSPCs) are self-renewing cells that generate important parts of the nervous system including neurons and glia during embryonic development. Adult NSPCs exist within specific regions of the brain and produce neurons continuously through a vertebrate’s lifetime. NSPCs are crucial to proper brain function and an integral aspect to overall brain health and pathology.

Cannabichromene (CBC) seems to display a positive effect on NSPCs viability within mice during in vitro differentiation. [1] This is promising as NSPCs differentiate into astroglial cells which are a highly important to proper brain homeostasis and an array of crucial developmental brain functions. These star-shaped cells work with neurons in the brain to increase neurotransmission, support energy metabolism, defend against oxidative stress, and aid ion homeostasis. When astrocytes become compromised due to pathological activity, it can compromise neuronal function and potentially lead to such conditions as Alzheimer’s disease and hepatic encephalopathy. [2]

CBC seems to encourage extracellular signal-regulate kinases 1 and 2 (ERK1/2) phosphorylation while exhibiting this effect more slowly than normal mitogen-activated protein kinase stimulation. [1] The adenosine A1 receptor in the brain seems to be involved in the positive effects that CBC has in increasing viability of NSPCs. [1] ATP levels are also found in higher numbers during differentiation in the presence of CBC. [1] These findings indicate that CBC can possibly increase the viability of NSPCs while slowing the neural stem cells differentiation into astroglial cells.

References

  • Shinjyo, Noriko, Di Marzo, Vincenzo. The effect of Cannabichromene on adult neural stem/progenitor cells. Neurochem Internatinoal. Nov 2013. Journal Impact Factor 3.603 Times Cited = 25
  • Bélander, Mireille. The role of astroglia in neuroprotection. Dialogues Clin Neuroski. Sep 2009.