As discussed in our previous post, despite their apparent similarities, THCV and THC actually differ quite a bit.

Let’s examine the various medical benefits of THCV outside of its properties that help treat metabolic disorders.

Anxiolytic and Energizing

Because THCV actually acts as an CB1 antagonist in smaller amounts and blocks this receptor, it actually counters the effects of THC to a certain extent. As a result, the combination of the two compounds can produce a shorter, but more uplifting high, devoid of the lingering lethargy and drowsiness that is often associated with THC bombs, and can thus benefit people who require THC but also need to stay relatively clear-headed.

As we know, larger quantities of THC can cause anxiety, and since THCV can mitigate THC’s effects, cultivars rich in THCV are less likely to cause such episodes. Furthermore, THCV can stimulate 5-HT1A receptor activation and produce antipsychotic effects that can help people with schizophrenia and PTSD. [1]

Neuroprotective

THCV, as a lot of other cannabinoids, is a known antioxidant, and as such, it battles neurodegeneration by warding off free radicals and preventing them from inflicting oxidative damage to the brain. On top of that, it blocks CB1 receptors while activating CB2 receptors, making it a great candidate for battling neurodegenerative diseases.

Indeed, THCV has demonstrated serious potential in that regard. It battles brain lesions and mitigates the motor inhabitation, caused by 6-hydroxydopamine, thus delaying the progression of Parkinson’s disease and alleviating symptoms like tremors. [2]

This is why some people bank on THCV to battle Alzheimer’s as well, but more research needs to be done.

Bone Growth

THCV has been found to “stimulate the recruitment of quiescent mesenchymal stem cell present in bone marrow,” [3] which in layman’s terms means it aids bone formation. This property can have major implications for people who suffer from osteoporosis and other bone conditions.

Anti-Inflammatory and Analgesic

THCV has also demonstrated some anti-inflammatory effects, alleviating both inflammation and inflammatory pain in a study with mice. [4] This property was once again tied to is ability to block CB1 receptors while activating CB2 receptors.

As you can see, THCV has some serious medicinal potential which spans a number of different applications

References:

  1. Cascio et al, “The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act through 5-HT1A receptors to produce antipsychotic effects” Br J Pharmacol. 2015 Mar; 172(5): 1305–1318. Journal Impact Factor = 6.81; Times Cited = 17
  2. García et al, “Symptom‐relieving and neuroprotective effects of the phytocannabinoid Δ9‐THCV in animal models of Parkinson’s disease” British Pharmacological Society 16 February, 2011; Journal Impact Factor = 4.842; Times Cited = 109
  3. Ligresti et al, “From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology” Physiological Reviews 96, No. 4; 14 September 2016; Journal Impact Factor = 24.014’ Times Cited = 113
  4. Bolognini et al, “The plant cannabinoid Δ9‐tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice” British Pharmacological Society, 19 May 2010; Journal Impact Factor = 4.842; Times Cited = 57

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